阿昔洛韦联合窄谱中波紫外线治疗带状疱疹临床效果及预防疱疹后遗神经痛价值分析

摘要

目的：探讨阿昔洛韦联合窄谱中波紫外线治疗带状疱疹的临床效果，分析其预防疱疹后遗神经痛的价值。方法将137例带状疱疹患者依据随机数表法分为对照组（n＝67）和治疗组（n＝70）。两组患者均采用常规对症治疗，对照组患者给予阿昔洛韦治疗，治疗组患者在对照组基础上给予窄谱中波紫外线治疗。两组患者疗程均为2周。比较两组患者临床疗效，症状、体征恢复时间，视觉模拟评分法（VAS）评分，血清细胞因子水平，不良反应发生情况及随访后遗神经痛发生情况。结果治疗组患者治疗总有效率显著高于对照组（P＜0.05），止疱时间、结痂时间、脱痂时间及疼痛缓解时间均短于对照组（P＜0.05）。两组患者治疗前VAS评分比较差异无显著性（P＞0.05）；治疗后两组患者VAS评分均较治疗前明显减少（P＜0.05），治疗组低于对照组（P＜0.05）。治疗组患者治疗后血清白细胞介素-6（IL-6）、C反应蛋白（CRP）水平均显著低于对照组（P＜0.05）。治疗期间两组患者均未见明显不良反应发生。随访6个月，治疗组患者疱疹后遗神经痛发生率显著低于对照组（P＜0.05）。结论阿昔洛韦联合窄谱中波紫外线治疗带状疱疹疗效显著，且可明显预防疱疹后遗神经痛。%ObjectiveTo investigate the clinical effect of acyclovir combined with narrow-band UVB (NB-UVB) phototherapy in the treatment of herpes zoster, analyse the prevention of postherpetic neuralgia value. Method137 patients with herpes zoster were divided into control group (n=67) and treatment group (n=70) according to the random number table method. Two groups were treated with conventional symptomatic treatment, control group patients were treated with acyclovir, treatment group patients were treated with NB-UVB on the basis of treatment group. Two groups of treatment for 2 weeks. Compared two groups of patients with clinical curative effects, recovery time of symptoms and signs, visual analogue scale (VAS), the changes of serum cytokine levels and adverse reactions occur and follow-up of postherpetic neuralgia occurrence.ResultThe total effective rate in treatment group was higher than control group (P<0.05). The cessation time, scab, decrustation, pain relief time in treatment group were shorter than control group (P<0.05). There was no significant difference in VAS scores between the two groups before treatment (P>0.05); after treatment, the VAS scores of two groups were signiifcantly lower than before treatment (P<0.05), and treatment group was lower than control group (P<0.05). After treatment, the levels of serum IL-6 and CRP in treatment group were lower than control group (P<0.05). There were no obvious adverse reactions in the two groups during the treatment period. After 6 months of follow-up, treatment group patients with postherpetic neuralgia incidence was signiifcantly lower than control group (P<0.05).Conclusion Acyclovir combined with NB-UVB in the treatment of herpes zoster has curative effect, and can signiifcantly prevent postherpetic neuralgia.