Objective To analyze the relationship between insulin resistance and sex hormones in patients with polycystic ovary syndrome (PCOS).Method 50 patients with PCOS from February 2014 to February 2016 in the Second Affiliated Hospital of Xi'an Jiao Tong University were selected in observation group, during the same period 50 healthy women of childbearing age volunteers were selected in control group. Plasma insulin levels were measured by insulin release test in all subjects, and serum sex hormone levels were measured by 3～5 days in the menstrual cycle. The levels of plasma insulin and sex hormone and the incidence rate of insulin resistance were compared between the two groups, the correlation between the level of insulin resistance and androgen in observation group were analyzed.Result Fasting, after taking 1 hour, after taking 2 hours, after taking 3 hours, the levels of plasma insulin and the incidence rate of insulin resistance in observation group were significantly higher than those in control group (P<0.05). The level of insulin resistance in observation group was positively correlated with the level of testosterone and estradiol (r=0.446, 0.453,P<0.05); the levels of follitropin and estradiol in observation group were significantly lower than those in control group (P<0.05); the levels of luteinizing hormone and testosterone in observation were significantly higher than those in control group (P<0.05).Conclusion Patients with PCOS have insulin resistance and hyperandrogenemia, insulin resistance can significantly promote the secretion of male hormones.%目的 分析多囊卵巢综合征患者胰岛素抵抗与性激素的关系.方法 将2014年2月至2016年2月西安交通大学第二附属医院收治的50例多囊卵巢综合征患者纳入观察组,另选取本院同期50例健康育龄女性志愿者纳入对照组.所有研究对象均行胰岛素释放试验测定血浆胰岛素水平,并于月经周期3～5天采集肘静脉血测定性激素水平.比较两组研究对象血浆胰岛素水平、性激素水平及胰岛素抵抗发生率,并分析观察组患者胰岛素抵抗水平与其雄激素水平的相关性.结果 空腹、服糖后1小时、服糖后2小时、服糖后3小时,观察组患者血浆胰岛素水平和胰岛素抵抗发生率均显著高于对照组(P<0.05).观察组患者胰岛素抵抗水平与睾酮和雌二醇水平均呈正相关(r=0.446、0.453,P<0.05).观察组患者促卵泡素和雌二醇水平均显著低于对照组(P<0.05),促黄体生成素和睾酮水平均显著高于对照组(P<0.05).结论 多囊卵巢综合征患者存在胰岛素抵抗和高雄激素血症,胰岛素抵抗可显著促进雄激素分泌,临床治疗中需要重点关注.
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