目的 探讨普瑞巴林联合鼠神经生长因子治疗带状疱疹后遗神经痛的临床效果.方法 选取本院2014年7月至2016年7月收治的120例带状疱疹后遗神经痛患者为研究对象,按照简单随机法将入选患者分为普瑞巴林组(单用普瑞巴林治疗)、鼠神经生长因子组(单用鼠神经生长因子治疗)和联合治疗组(普瑞巴林联合鼠神经生长因子治疗).比较三组患者治疗前后视觉模拟评分法(visual analogue scale,VAS)评分、疗效及治疗后不良反应发生情况.结果治疗后三组患者VAS评分均显著低于治疗前(P<0.05);治疗1周、2周及4周后,联合治疗组患者VAS评分均显著低于同期普瑞巴林组和鼠神经生长因子组(P<0.05).联合治疗组患者治疗有效率明显高于普瑞巴林组和鼠神经生长因子组(P<0.05).联合治疗组患者不良反应发生率高于普瑞巴林组和鼠神经生长因子组,但组间比较无显著差异(P>0.05).结论 普瑞巴林联合鼠神经生长因子治疗带状疱疹后遗神经痛可有效改善患者疼痛症状,效果显著,不良反应较轻,具有较高安全性.%Objective To explore the effect of Pregabalin combined with mouse nerve growth factor in the treatment of postherpetic neuralgia. Method From July 2014 to July 2016, 120 cases of postherpetic neuralgia patients treated in our hospital were selected as the research objects. According to the simple random method, they were divided into Pregabalin group (treated by Pregabalin), mouse nerve growth factor group (treated by mouse nerve growth factor) and combination group (treated by Pregabalin combined with mouse nerve growth factor). The visual analogue scale (VAS) scores before and after treatment, treatment effects and adverse reactions after treatment were compared among the three groups. Result After treatment, the VAS scores of the three groups were significantly lower than those before treatment (P<0.05); 1 week, 2 weeks and 4 weeks after treatment, the VAS scores of combination group were significantly lower than Pregabalin group and mouse nerve growth factor group at the same period (P<0.05). The effective rate of combination group was significantly higher than that of Pregabalin group and mouse nerve growth factor group (P<0.05). The occurrence of adverse reactions of combination group was higher than Pregabalin group and mouse nerve growth factor group, but there were no significant differences among the three groups (P>0.05). Conclusion Mouse nerve growth factor combined with Pregabalin in the treatment of postherpetic neuralgia, can alleviate the pain symptoms of patients, and has significant curative effect, mild adverse reactions, higher safety.
展开▼
