TORCH 病原体感染与自然流产的关系及影响因素

摘要

目的：探讨TORCH病原体感染与自然流产的相关性，分析其可能的影响因素。方法对2012年9月至2014年9月于四川省人民医院就诊的831例妇女采用化学发光法进行TORCH－IgM及IgG四项检测，将363例有自然流产史的妇女纳入A组，468例无自然流产史妇女纳入B组，比较两组TORCH感染阳性率及影响因素。结果 A组妇女HSV－IgG（64.4％）、CMV－IgM（5.0％） Tox－IgM（5.8％）及HSV－IgM（9.1％）抗体的阳性率均高于B组（分别为57.1％、1.9％、2.6％、5.6％）（P＜0.05）。在A组中，农村妇女巨细胞病毒（cytomegalovirus，CMV）、弓形虫（toxoplasma， Tox）、风疹病毒（rubella virus， RV）、生殖器单纯疱疹病毒（herpes simplex virus，HSV）病原体的感染率分别为7.1％、7.6％、7.6％、12.1％均高于城市（2.4％、1.8％、3.6％、4.4％）（ P＜0.05）；有动物接触史的妇女TORCH检出率高于无动物接触史的妇女（ P＜0.05）。结论 TORCH病原体感染与自然流产密切相关，农村、有动物接触史为TORCH感染的高危因素。%Objective To investigate the correlation between TORCH infections and natural abortion, to analyze the potential influence factors.Methods A total of 831 women were detected by chemiluminescence method in Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital from Sept.2012 to Sept.2014, 363 women with natural abortion history were selected into group A and 468 women without natural abortion history were divided into group B, the positive rates of TORCH and influence factors were compared.Results The positive rates of HSV-IgG, CMV-IgM, Tox-IgM and HSV-IgM in group A [64.4%、5.0%、5.8 %、9.1 %respectively]were higher than that in group B(57.1 %、1.9 %、2.6 %、5.6 % respectively) (P<0.05).In group A, infections of cytomegalovirus(CMV), toxoplasma (Tox) and herpes simplex virus (HSV) of the women in rural [7.1%、7.6%、7.6 %、12.1 % respectively]were higher than that in urban[2.4 %、1.8 %、3.6 %、4.4 % respectively] (P<0.05).TORCH positive rate of women who have history of exposure to animals was higher than that without history of exposure to animals(P<0.05). Conclusion TORCH pathogens infection was related with natural abortion, rural area, and history of exposure to animals were high risk factors of TORCH infections.