Objective The aim of study is to explore the TORCH infection status on the pre-pregnancy women and analyze the relationship with pregnancy outcome in Hongkou District,Shanghai,and provide the reference for the eugenic and superi-or nurture.Methods Enzyme linked immunosorbent assay (ELISA)was used to detect the specificity antibodies to Toxo-plasma (TOX),Rubelavirus (RUV),Cytomegalovirus (CMV)IgG and IgM in sera of the 3 500 pre-pregnant women in Hongkou District,Shanghai.Chi-square test was used for comparative analysis of the different rates.Results The positive rate of TOX-IgG,TOX-IgM,RV-IgG,CMV-IgG and CMV-IgM in pregnancy women from Hongkou district were 1.37%, 0.34%,89.7%,96.2% and 0.60% respectively.The total positive rate of TOX and (or)CMV IgM was 0.94%.According to age group,the results showed that TORCH infections with three pathogens associated with the pre-pregnancy women’s age,and the difference was statistically significant (χ2=102.9,P<0.01).The abnormal pregnancy rate of TORCH infec-tion-positive pregnancy women (25.0%,3/12)was higher than that of TORCH-negative pregnancy women (6.62%,27/408),and the difference was statistically significant (χ2 =4.43,P=0.04).Conclusion The infection opportunity of TORCH in pregnant women in Shanghai Hongkou district was obviously existent and the TORCH infection status could effect on pregnancy outcome.TORCH testing has important practical significance as a routine examination of the pre-preg-nancy healthy service.%目的：了解上海市虹口区孕前妇女TORCH病原体的感染情况及对妊娠结局的影响，为优生优育提供信息参考。方法采用酶联免疫吸附法（ELISA）对上海市虹口区3500例孕前妇女检测弓形虫（TOX）、风疹病毒（RV）和巨细胞病毒（CMV）等TORCH三种病原体的特异性 IgM和 IgG抗体。率的比较采用卡方检验分析。结果调查的上海市虹口区孕前妇女弓形虫 IgG，IgM和风疹病毒IgG、巨细胞病毒IgG和IgM阳性率分别是1.37％，0.34％，89.7％，96.2％和0.60％。弓形虫和（或）巨细胞病毒 IgM的总阳性率为0.94％。根据年龄分组发现，TORCH三种病原体感染情况与妇女年龄有显著关系，差异具有统计学意义（χ2＝102.9，P＜0.01）。其中TOX-IgM阳性以25～35岁年龄妇女较多，而 CMV-IgM阳性主要分布在25～35岁年龄妇女。追踪TORCH感染和孕妇妊娠结局发现 TORCH 三种病原体感染阳性的孕龄妇女发生妊娠异常的比例（25.0％，3/12）高于TORCH阴性妇女（6.62％，27/408），差异有统计学意义（χ2＝4.43，P＝0.04）。结论上海虹口区孕前妇女TORCH感染的几率明显存在，可影响妊娠结局。TORCH 检测应作为孕前优生健康检查的常规检查项目推广。
展开▼
