新生血管性年龄相关性黄斑变性和息肉状脉络膜血管病变的分子生物学研究现状及存在问题

摘要

Neovascular age-related macular degeneration(nAMD)and polypoidal choroidal vasculopathy (PCV)are leading causes of blindness and visual impairment in older population.They are both with a hemorrhagic and exudative macular disorder.PCV has been proposed to be a sub-type of nAMD,hut this is a matter of controversy.Although several genes are found to be associated with PCV and nAMD(CFH,ARMS2/HTRA1),but more genes show no common association with the two diseases.such as BF/C2,Elastin,PEDF,SERPlNG1,VEGF,APOE genes.All these Results might imply that PCV and nAMD have different pathogenesis.But in the current state of our knowledge for PCV and nAMD.we still could not conclude if they are the same diseases.The purpose of these review is to discuss the recent progress in the molecular biology of PCV and nAMD.%新生血管性年龄相关性黄斑变性(nAMD)和息肉状脉络膜血管病变(PCV)是常见的引起老年人致盲和严重视力损害的眼病,都以黄斑区出血和渗出为特征.近年来,关于PCV是否为nAMD的一种亚型存在着争论.nAMD和PCV具有部分相同的强关联易感基因位点(CFH,ARMS2/HTRA1),但在更多不同的基因位点(如BF/C2,Elastin,PEDF,SERPING1,VEGF,APOE等基因)上存在区别,这可能提示了PCV和nAMD在病因学上存在差异.但就目前nAMD和PCV的研究现状,尚无法严格地将其定义为两种不同的疾病.就nAMD和PCV的分子生物学研究现状和存在问题进行阐述.