视网膜母细胞瘤的研究进展

摘要

Retinoblastoma(RB) is the most common infant malignant tumor of eye.It seriously affects the life quality and life span.The rapid development of biological technology allows some new breakthroughs in the basic and clinical researches of RB.Current researches focus on its etiology and pathogenesis,and the ultimate aim is to guide clinical prevention,detection and management.Some literature revealed and summarized the histological source of RB,mutation detection of Rb gene,hereditary clue of RB susceptibility,and gene-therapy of RB.Gene therapy of RB is a new treating approach to RB in recent years,and its development brings a chance for achieving the goal of curing RB and improving patient prognosis.The research progress of RB is reviewed here.%视网膜母细胞瘤(RB)是婴幼儿最常见的眼内恶性肿瘤,严重影响患儿的视力,甚至可危及生命.随着生物学技术的提高,RB的研究已取得一些突破.目前的研究主要集中于阐明其病因及发病机制,最终目的是用于指导临床预防、检测和治疗.基因治疗RB是近年来新型的治疗方法,为RB的治疗及预后的改善带来了契机,有望成为继手术、化学治疗、放射治疗之后一种全新的治疗模式.就RB肿瘤细胞的组织来源、Rb基因突变的检测、RB遗传易感性的研究及基因治疗实验研究的发展方向等进行系统综述.