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Method for detecting the predisposition to retinoblastoma and method for detecting a retinoblastoma gene defect in tumors using a retinoblastoma gene probe
Method for detecting the predisposition to retinoblastoma and method for detecting a retinoblastoma gene defect in tumors using a retinoblastoma gene probe
A Method of and a kit for detecting the predisposition to retinoblastoma. A method for detecting a defect in the retinoblastoma gene in retinoblastoma, osteosarcoma, fibrosarcoma, melanoma, soft tissue sarcoma, small-cell carcinoma and mammary tumors. The method includes hybridizing a retinoblastoma gene probe to DNA extracted from target tissue and then determining binding of the probe to the DNA. The target tissue can be tumor or non-tumor tissue and from a fetus to an adult. Further there are DNA probes of 4.6, 3.8, and 0.9 kb.
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