坏死性凋亡与视网膜细胞死亡相关性的研究进展

摘要

视网膜色素上皮细胞、神经节细胞、光感受器细胞等视网膜细胞在维持视网膜和脉络膜功能上发挥了重要作用.视网膜细胞的死亡是多种眼病引起视功能损害的主要原因.坏死性凋亡是一种新的重要的细胞死亡途径.本文就坏死性凋亡的发现及其分子机制及坏死性凋亡在年龄相关性黄斑变性、视网膜脱离等多种视网膜疾病中的研究现状进行综述,为视网膜疾病的防治提供新的思路.%Retinal pigment epithelium cells, retinal ganglial cells and photoreceptor cells play vital roles in maintaining the function of retina and choroid.Retinal cell death is the main cause of vision loss in ocular diseases.Necroptosis is a newly found way of programmed cell death.This article presented the mechanism of necroptosis and its research progess in different retinal diseases such as age-related macular degeneration and retinal detachment,which may provide new approaches for retinal diseases treatment.