Background The histopathological and functional changes are affected by age,gender and axial length (AL).However,whether these factors affect the volume and thickness of various layers of retina is not elucidated.Understanding macular intraretinal layer volume changes and influence factors can offer useful information for relevant clinical study.Objective This study was to measure the influence of age,gender and AL on the volume of individual retinal layers at macula zone with optical coherence tomography (OCT) in normal population.Methods A cross-sectional study was carried out under the approval of Ethic Committee of Tongling People's Hospital.One hundred and thirty-four eyes of 92 healthy individuals who received physical examinations and ocular examinations by slit lamp microscope,90 D pre-set lens,RM-8000A computer automatic optometry and non-contact tomometer were recruited from April to July 2016.The individuals were grouped based on gender or ages (7-14 years group,15-49 years group,50-80 years group).The retinal thickness and volume of different layers within 6 mm circle area around fovea were measured by Spectral-OCT with Posterior Pole mode and processed by the layered software.AL was measured with ODM-2100 A/B ultrasonic apparatus.Results The volume values of whole retinal thickness (WRL),retinal nerve fiber layer (RNFL),inner nuclear layer (INL) and outer plexiform layer (OPL) in males were (8.80 ± 0.38),(0.92 ± 0.09),(1.03 ± 0.07) and (0.79 ± 0.07) mm3,which were significantly increased in comparison with (8.66±0.34),(0.88±0.07),(1.00±0.07) and (0.77±0.06)mm3 in females (P=0.025,0.027,0.012,0.030).The WRL,GCL and IPL volume values were largest in the 15-49 years group and least in the 7-14 years group,and the volume values of RNFL,outer nuclear layer (ONL),retinal pigment epithelium (RPE) and photoreceptors (PC) were significantly lower in the 7-14 years group and 50-80 years group than those in the 15-49 years group (all at P ＜ 0.01).The AL was negatively correlated with WRL,GCL and IPL volumes (r=-0.226,-0.385,-0.373,all at P＜0.01).Conclusions The retinal volume value at macular area is larger in men than that in women.The retinal volume area shows firstly increased and then decreased during aging.The AL shows a negative correlation with the macular volume.%背景 正常人的视网膜组织形态和生理功能受年龄、性别、眼轴长度(AL)等因素的影响,但黄斑区视网膜分层容积是否受年龄、性别和AL影响的量化分析较少,了解相关信息可为相关的临床研究提供参考依据. 目的 采用频域光相干断层扫描(OCT)仪对正常人黄斑区视网膜各层容积进行测量,分析年龄、性别和AL对视网膜各层容积的影响.方法 采用横断面研究方法,于2016年4-7月纳入在铜陵市人民医院体检且经裂隙灯显微镜和90 D前置镜检查、RM-8000A型电脑自动验光仪和非接触眼压计测定证实眼部正常的受检者92人134眼.将受检者按照不同性别分为2个组,并按照年龄不同分为7 ～14岁组、15 ～49岁组和50 ～ 80岁组.采用Spectral-OCT仪在Posterior Pole模式下对黄斑中心凹为中心、直径为6 mm圆形区域内的视网膜厚度进行测量,并获取黄斑区视网膜各层容积;采用ODM-2100型A/B超声仪测量AL. 结果 男性黄斑区视网膜全层(WRL)、视网膜神经纤维层(RNFL)、内核层(INL)和外丛状层(OPL)容积分别为(8.80±0.38)、(0.92±0.09)、(1.03±0.07)和(0.79±0.07)mm3,较女性的(8.66±0.34)、(0.88±0.07)、(1.00±0.07)和(0.77±0.06)mm3明显增厚,差异均有统计学意义(P=0.025、0.027、0.012、0.030).3个年龄组中15 ～ 49岁组受检者黄斑区WRL、节细胞层(GCL)、和内丛状层(IPL)黄斑区容积最大,7～14岁组最小,7～14岁组和50 ～ 80岁组黄斑区RNFL、外核层(ONL)、视网膜色素上皮(RPE)和光感受器层(PC)容积均小于15 ～ 49岁组,差异均有统计学意义(均P＜0.01).受检者AL与黄斑区WRL、GCL、IPL容积均呈线性负相关(r=-0.226、-0.385、-0.373,均P＜0.01). 结论 正常男性黄斑区视网膜容积较女性增厚,儿童到老年期间黄斑区视网膜容积呈先增加后减少的趋势,AL与黄斑区视网膜容积呈负相关.
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