婴幼儿肠套叠与轮状病毒性腹泻分布特征分析

摘要

目的 了解苏州市婴幼儿肠套叠的发病状况及肠套叠与轮状病毒性腹泻是否存在关联.方法 采用回顾调查的方法 ,以<2岁的婴幼儿为对象,统计1999-2003年在门诊和住院的肠套叠病例.采用ELISA法对2001年9月至2003年8月2岁以下的腹泻住院患者的粪便标本进行病毒抗原测定.结果 苏州市2岁以下的肠套叠患儿1101例,1999-2003年1岁以下肠套叠的发病率分别为:275.3/10万、338.2/10万、547.0/10万、515.3/10万、425.4/10万,平均年发病率为418.1/10万.肠套叠以4-10个月最常见.共692例(62.85%).平均年龄(9.62±5.65)月.轮状病毒性腹泻是以5~16个月最常见,共252例(76.13%).平均年龄(11.42±5.14)月.两组间发病年龄经比较,z=-15.52,P<0.01.肠套叠的发病高峰季节在4~8月份,共595例(54.04%).而轮状病毒性腹泻的发病的高峰季节在10月至次年1月,共232例(70.09%).两组问发病的季节的分布进行统计学检验,X2=226.06,P<0.001.结论 流行病学的资料显示肠套叠与轮状病毒性腹泻的相关性有待进一步研究.%Objective To investigate the annual incidence rate of intussusception over a 5-year period in Suzhou and to determine whether there was a potential link between intussusception rotavirus diarrhea. Methods Outpatient and inpatient data from 1999 through 2003 retrospectively were reviewed for young children (<2 year old) whose diagnosis was confirmed by ultrasonography or radiography and patients were reduced by air enema or surgery. From September. 2001, to August. 2003, inpatients with diarrhea (<2 year old) were detected rotavirus antigen in the stool by ELISA technology. Results From 1999 through 2003, 1101 cases were reported in children below 2 years old. The incidence rate of intussusception under 1 year age each year was 275.3, 338.2, 547.0,515.3,and 425.4 per 100 000 child years respectively(the average annual incidence was 418.1 per 100 000 child years),and the incidence of intussusception increased over time from 1999 to 2003. A peak age distribution of intussusception was infants 4 to 10 months old (692/1101,62.85%) and mean age was 9.62±5.65 months, which were greatly different from those of patients with rotavirus diarrhea, whose peak age distribution was 5 to 16months old (252/331,76.13%), and mean age was 11.42±5.14 months(Z=6.90,P<0.01). The peak month distribution of intussusception was from April to August (595/1101,54.04%), which was distinct from that of patient with rotavirus diarrhea, whose peak month distribution was between October and January (232/331,70.09%). Test: X2=226.06,P<0.001. Conclusion The annual incidence rate of intussusception for<1 year of age was 418.1 per 100000 child years in Suzhou. We found no epidemiologic evidence for an association between intussusception and rotavirus diarrhea.