北京地区人乳头瘤病毒39型的人群分布特征

摘要

目的 研究北京地区人乳头瘤病毒(human papillomavirus,HPV) 39型的感染情况及分布规律.方法 收集2013年1月至2014年7月就诊于中国人民解放军总医院妇产科,并在30天内同时进行宫颈脱落细胞HPV分型检测及新柏氏薄层液基细胞学检测的女性患者,回顾性收集其临床信息.通过聚合酶链式反应对HPV39阳性样本进行HPV39病毒基因组全长扩增.结果 19 018例受试者中,HPV39阳性为518例,阳性率为2.72％,且在21-25岁组和46-50岁组呈现感染高峰,其阳性率分别为2.98％和2.44％.在宫颈病变中,HPV39在低度鳞状上皮内病变中的阳性率最高,为18.52％.共扩增出5例HPV39阳性样本的病毒全基因组.结论 HPV39随年龄增大呈双峰分布,且在低度鳞状上皮内病变中占有较高的比例.宿主细胞中存在附加体形式的HPV39.%Objective To investigate the infection rate and distribution of human papillomavirus type 39 in Beijing.Methods HPV genotyping detection coupled with cytological test of cervical exfoliated cells within 30 days were used for the patients from the People's Liberation Army General Hospital,between January 2013 to July 2014.Full-length genomes were amplified for the HPV39 positive samples.Results Among 19 018 samples,518 were HPV39 positive (2.72％).Two peaks were observed in the age groups 21-25 and 46-50 years old,with positive rate of 2.98％ and 2.44％ respectively.The prevalence of HPV39 in low-grade squamous intraepithelial lesion (LSIL) was 18.52％,higher than other cervical lesion groups.In addition,full-length genome amplifications were successful in five HPV39 positive samples.Conclusions In the studied population,HPV39 showed two increases in age groups,and abundance in LSIL.Episomal form of HPV39 viral genomes existed in the samples.