Distribution of human papillomavirus genotype and cervical neoplasia among women with abnormal cytology in Beijing, China

摘要

Objective: To understand the relationship between human papillomavirus (HPV) genotype distribution and cervical neoplasia among women with abnormal cytology in Beijing. Methods: In a study in Beijing, China, participants underwent a gynecologic examination between September 2006 and December 2009. Those with abnormal cytology underwent colposcopy, biopsy, and HPV testing. HPV was typed by flow-through hybridization on formalin-fixed paraffin-embedded tissue. Results: Among 6339 women examined, 533 with abnormal cytology underwent HPV testing. The prevalence of high-risk HPV (HR-HPV) subtypes was 29.8%. HPV-16 was the most common genotype (12.8%), followed by HPV-33, HPV-58, HPV-66, HPV-18, and HPV-52. The cytologic and histopathologic grade clearly increased with a higher prevalence of HR-HPV infection. Both HPV-16 and HPV-33 were significantly associated with grade CIN2 + lesions (P < 0.05). By contrast, HPV-18 and HPV-66 were not associated with cervical lesion severity. HR-HPV infection was most common among women aged 30-34 years (35.0%). Conclusion: HPV-16, HPV-58, HPV-33, HPV-66, HPV-18, and HPV-52 were the most common genotypes in Beijing. HPV-16 and HPV-33 might be associated with CIN2 + lesions. HPV-18 and HPV-66 were not associated with high-grade cervical lesions. The present results might help to improve HPV vaccination and cervical cancer prevention programs in Beijing.