Chromosome 11 and Transcription Regulation of Human Papillomavirus Type 16

摘要

Strong evidence exists for a causative role of specific human papillomavirus (HPV) types (e.g. HPV16) in the development of cervical cancer. Several observations e.g. the long latency period between HPV infection and the development of cervical cancer and the presence of the same oncogenic HPV types in cervical intraepithelial neoplasia (CIN) lesions as in cervical cancer strongly suggest that secondary events are required for the development of malignancy. The results described in the thesis will be discussed in the scope of the role of chromosome 11 on the transforming potential of HPV16.