Objective To investigate effects on growth differentiation factor 15 and hs-CRP in patients with aged type 2 diabetics with coronary heart disease by different treatment.Methods A total of 70 patients with coronary heart disease complicated with type 2 diabetes were selected from January 2014 to June 2015 in The First People's Hospital of Wujiang in Suzhou. The patients were randomly divided into two groups; each group has 35 patients. Patients of control group were given atorvastatin combined with aspirin, patients of observation group were received glargine insulin on the basis of treatment of control group. Blood sugar control, level of growth differentiation factor 15 and hs-CRP were measured.Results After treatment, level of fasting blood-glucose [(8.56 ±1.20) mmol/L], 2-hour postprandial blood glucose [(8.97±1.01) mmol/L] and glycosylated hemoglobin [(7.01± 1.02) %] of observation group were decreased, and were better than control group (P<0.05). In control group, level of fasting blood-glucose was (9.93±1.50) mmol/L, level of 2-hour postprandial blood glucose was (9.01±1.50) mmol/L and level of glycosylated hemoglobin was (9.87±1.54) % after treatment. Level of growth differentiation factor 15 and hs-CRP were both decreased in two groups (P<0.05) after treatment.Conclusion Atorvastatin Combined with insulin glargine can effectively control blood sugar and improve expression of growth differentiation factor 15 and hs-CRP in patients with aged type 2 diabetics with coronary heart disease compared to traditional treatment.%目的：探讨不同治疗方法对老年冠心病合并2型糖尿病患者血糖控制前后生长分化因子15及高敏C反应蛋白（hs-CRP）的影响。方法选取2014年1月~2015年6月于吴江区第一人民医院收治的老年冠心病合并2型糖尿病患者70例，随机分为两组，每组35例，对照组给予阿托伐他汀和阿司匹林，观察组在此基础上给予甘精胰岛素，比较血糖控制效果及生长分化因子15、hs-CRP水平。结果观察组治疗后的空腹血糖（8.56±1.20）mmol/L、餐后2 h血糖（8.97±1.01）mmol/L、糖化血红蛋白（7.01±1.02）%相比于治疗前均下降，且优于对照组治疗后空腹血糖（9.93±1.50）mmol/L、餐后2 h血糖（9.01±1.50）mmol/L、糖化血红蛋白（9.87±1.54）%水平，（P均＜0.05），治疗后两组生长分化因子15、hs-CRP较治疗前均下降（P＜0.05）。结论阿托伐他汀结合甘精胰岛素治疗老年冠心病合并2型糖尿病，相比于传统治疗方式能更有效的控制血糖并改善患者生长分化因子15、hs-CRP表达。
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