抗心律失常药不良反应的文献分析

摘要

目的：研究抗心律失常药不良反应（ADR）发生的特点及规律，为临床药品的选择和ADR的判断提供参考。方法对1995～2015年文献报道的326例抗心律失常药ADR病例进行统计分析。结果在326例ADR病例中，男性患者187例（57.4%），女性患者139例（42.6%）；抗心律失常药物分类中，I类抗心律失常药引起的ADR共115例（35.3%），所占比例最高；胺碘酮是引起最多ADR的单个药物，共108例（33.1%）；严重ADR共155例（47.5%）。结论临床应重视对抗心律失常药应用监测，掌握药品信息，减少不良反应的发生。%Objective To study the characteristics and laws of adverse reactions (ADR) of antiarrhythic drugs, and provide the reference for selection of drugs and determination of ADR in clinic.Methods The cases of ADR of antiarrhythic drugs (n=326) reported from 1995 to 2015 were counted and analyzed.Results Among 326 ADR cases, there were 187 (57.4%) male cases and 139 (42.6%) female cases. In the aspect of drug classification, there were 115 cases (35.3%) of ADR induced by type I antiarrhythic drugs, which had the highest ratio. There were 108 cases (33.1%) of ADR induced by amiodarone, and it was a single drug induced the most cases of ADR. There were totally 155 (47.5%) cases of severe ADR.Conclusion The administration of antiarrhythic drugs should be paid more attention to and drugs information should be mastered for reducing ADR.