多囊卵巢综合征患者血脂代谢的特点分析

摘要

将92例多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者分别按鹿特丹标准、肥胖与否、是否存在高胰岛素血症分为不同的亚型,检测记录她们的临床体征及女性内分泌激素水平,同时检测空腹血脂四项(总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇)浓度.比较结果提示:从PCOS患者血脂代谢的特点来看,鹿特丹标准未能反映PCOS患者血脂代谢的严重程度,临床应用中有一定局限性；对于肥胖合并高胰岛素血症的PCOS患者进行脂代谢早期干预和管理对预防PCOS远期并发症具有积极意义.%A cross-sectional study of 92 women with polycystic ovary syndrome(PCOS) was performed.The patients were composed of 4 groups according to the Rotterdam criteria and were also divided into 2 groups according to body mass index and divided into 2 groups according to insulin-releasing test.Anthropometric measurements were recorded,and hormonal profile was assessed by measuring FSH,LH,prolactin,and testosterone.The metabolic profile was investigated by measuring glucose and insulin level during oral glucose tolerance test (OGTT),then calculating the homeostasis model assessment (HOMA).Serum lipid levels,including total cholesterol,triglycerides,high-density lipoprotein-cholesterol,and low-density lipoprotein-cholesterol were determirned.The result suggests that the classification according to the revised 2003 Rotterdam consensus on diagnosis does not reflect dyslipidemia in PCOS.Dyslipidemia in hyperinsulinemic group and obesity group were more severe than that in non-hyperinsulinemic group and non-obese group ; this finding needs our attention in early treatment and prevention of late complications of PCOS.