1例49岁女性患者，因肺部感染、结缔组织病、类风湿关节炎入院。抗感染给予头孢哌酮钠/舒巴坦钠3.0 g，静脉滴注，bid，次日联合口服盐酸莫西沙星片400 mg，qd。应用抗菌药物6 d后，患者出现轻度肝功能损害。停用盐酸莫西沙星片，2 d后患者转氨酶持续升高，考虑为头孢哌酮钠/舒巴坦钠和莫西沙星引起的肝损害，停药给予还原型谷胱甘肽、复方甘草酸苷保肝降酶，持续10 d，患者转氨酶下降，逐渐恢复出院。%One 49-year-old female patient was hospitalized with lung infection, connective tissue disease and rheumatoid arthritis. The patient was intravenously administered cefoperazone sodium and sulbactam sodium with 3.0 g, twice a day. The next day, hydrochloride moxifloxacin tablet with 400 mg once a day was added. After the sixth day of antibacterial treatment, the patient suffered from slight liver damage. Hydrochloride moxifloxacin tablet was stopped immediately, and two days later, the patient's aminopherase continued to rise. The liver damage was considered to be induced by cefoperazone sodium and sulbactam sodium and moxifloxacin. Those antibacterials were stopped, and the patient was given GSH and compound glycyrrhizin for protecting liver and lowering transaminase. Ten days later, her aminopherase decreased, the symptoms gradually relieved and the patient was discharged.
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