从1例重症肺部感染患者探讨美罗培南的优化给药方案

摘要

1例80岁男性患者，既往合并癫痫等多种基础疾病，因肺部感染入院。入院时诊断为重症肺部感染，Ⅰ型呼吸衰竭，给予美罗培南等多种抗生素抗感染及对症支持治疗后，患者病情逐渐好转。基于该例重症肺炎患者，探讨延长美罗培南输注时间的给药方式优化给药方案的重要性和必要性。结果提示在保证药物稳定性的前提下延长美罗培南输注时间可提高临床疗效。%[ABSTRACT]One 80-year-old male patient with epilepsy and many other diseases was hospitalized because of pulmonary infection. The patient was diagnosed as severe pneumonia and typeⅠrespiratory failure. The patient received anti-infectious therapy including meropenem and other antibiotics as well as symptomatic treatments, and then the situation of patient improved gradually. The importance and necessity of optimized meropenem dosage regimen by prolonging infusion in patients with severe pneumonia was explored. If the stability of metopenem could be guaranteed, the anti-infectious efifcacy can be improved by prolonging infusion time.