Objective To observe the therapeutic effect of Jinlida granule combined with Tongxinluo capsule on stage IV diabetic nephropathy. Methods Totally 120 patients with type 2 diabetic nephropathy were randomly divided into treatment group and control group. All patients were given conventional therapy for one month to control blood pressure, blood glucose and blood lipid, and then the patients in control group were given irbesartan while the patients in treatment group were given Jinlida granule combined with Tongxinluo capsule. The two groups were treated for 12 weeks. Renal function, proteinu-ria in 24 hours and other haemorheology indexes were observed before and after treatment. Results The index of renal function , urine protein excretion and haemorheology before and after treatment displayed much differences between the two groups except low shear viscosity and fibrinogen in control group, and the differences were statistically significant ( P <0.01 orP < 0.05 ); Compared with the control group, the index of renal function and haemorheology in the treatment group were significantly improved except the BUN and low shear viscosity( P >0.05 ), and the differences were statistically significant ( P < 0.05 or P < 0.01 ). Conclusion The traditional Chinese medicine Jinlida granule combined with Tongxinluo capsule had favorable therapeutic effect of reducing proteinuria and improving renal function of DN patients.%目的 观察津力达颗粒联合通心络胶囊治疗IV期糖尿病肾病(DN)的疗效.方法 将120例IV期DN患者随机分为治疗组和对照组,每组各60例.2组均给予基础治疗,经1个月准备期,血糖、血压、血脂等达标后,对照组给予厄贝沙坦,治疗组给予津力达颗粒联合通心络胶囊.均治疗12周,观察治疗前后2组肾功能、24 h尿蛋白及血液流变学等指标的变化.结果 除对照组低切黏度与纤维蛋白原外,2组肾功能、尿蛋白定量、血流变学指标治疗前后比较差异均有统计学意义(P<0.01或P<0.05);与对照组比较,治疗组除血尿素氮与低切黏度差异无统计学意义(P＞0.05)外,肾功能及血液流变学等各指标均有改善,差异均有统计学意义(P<0.05或P＜0.01).结论 津力达颗粒联合通心络胶囊能有效降低DN患者尿蛋白、改善肾功能,具有良好的临床疗效.
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