Effects of Digoxin and Tongxinluo capsule combination treatment on oxidative stress, cytokines and vascular endothelial function in patients with chronic heart failure

摘要

Objective: To explore the effect of digoxin and Tongxin capsule combined therapy onoxidative stress, cytokines and vascular endothelial function in patients with chronic heartfailure, and provide help for clinical treatment of patients with chronic heart failure. Methods:95 cases of chronic heart failure in our hospital were randomly divided into observation group(47 cases) and control group (48 cases). Control group patients were given basic treatment, andobservation group received combination therapy of digoxin and Tongxinluo capsule, to detectand to investigate the changes of oxidative stress, cytokines and vascular endothelial function intwo groups of patients before and after treatment. Results: There was no significant differencein oxidative stress, cytokines and vascular endothelial function between the two groups ofchronic heart failure patients before treatment (P0.05). Compared with before treatment, themalondialdehyde (MDA) and cytokines [tumor necrosis factor-α (TNF-α), C-reactive protein(CRP), interleukin-6 (IL-6) and brain natriuretic peptide (BNP)] in two groups of patients withchronic heart failure after treatment decreased significantly (P0.05), while indexes relatedto endothelial function [hyperemic brachial artery diameter after reactive hyperemia, brachialartery diameter change rate, brachial artery endothelial dependent diastolic function (FMD),and brachial artery endothelium dependent diastolic function (NMD)] and related indexes ofoxidative stress [glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase(CAT)] were significantly increased (P0.05). The related indexes and oxidative stress indexes(GSH-Px, CAT and SOD) of observation group after the combined treatment in patients withendothelial function were significantly higher than the control group after treatment (P0.05).After treatment, cytokines and MDA levels were significantly lower than the control group(P0.05). Conclusions: Tongxinluo capsule combined with digoxin treatment significantlyimproved the oxidative stress, cytokines and vascular endothelial function levels in patientswith chronic heart failure, and has important clinical significance for the treatment of patientswith chronic heart failure.