糖尿病胃轻瘫患者胃电参数及多项相关血清指标变化分析

摘要

Objective To observe the changes of gastric electrical parameters and serum index in patients with dia-betic gastroparesis.Methods From October 2013 to November 2014, 64 cases of diabetic gastric gastroparesis patients were enrolled as the observation group, 64 cases of health subjects during the same period were enrolled as healthy control group, two groups’ gastric electrical parameters ( including primary frequency and normal slow wave rhythm) and serum gastrointesti-nal hormones [ including somatostatin ( SS) , vasoactive intestinal peptide ( VIP) , gastrin ( GAS) and motilin ( MTL) ] , NO, 5-HT,IL-1βand TNF-αindex were detected and compared, and compared the different classification of patients with these in-dicators.Results The observation group’ s gastric electrical parameters( including pre-prandial and postprandial primary fre-quency and normal slow wave rhythm)were lower than those of healthy control group ( P <0.05).Observation group’s serum SS,GAS and MTL were lower than healthy control group, but serum VIP was higher than healthy control group( P <0.05) . Observation group’ s NO, IL-1βand TNF-αwere higher than healthy control group ,5-HT was lower than healthy control group ( P <0.05) , and in patients with different grading, these indexes have significant difference, which appeared as level 1 >2 >3 >4 ( P <0.05).Conclusion Diabetes stomach paresis patients gastric electrical parameters and number of se-rum markers revealed large changes, and the different grade of diabetic gastroparesis patients also exist significant differences, which indicate the great value of monitoring of the disease.%目的：观察糖尿病胃轻瘫患者胃电参数及多项血清指标的变化。方法选取2013年10月—2014年11月诊治的64例糖尿病胃轻瘫患者为观察组，同期体检的健康同龄人64例为健康对照组，对2组的胃电参数（包括主频率及正常慢波节律比）及血清胃肠激素[包括生长抑素（ SS）、血管活性肠肽（ VIP）、胃泌素（ GAS）及胃动素（ MTL）]、一氧化氮（ NO）、5-羟色胺（5-HT）、白介素-1β（ IL-1β）、肿瘤坏死因子-α（ TNF-α）血清指标进行检测并比较，同时比较不同分级患者的上述检测指标。结果观察组的胃电参数指标包括餐前、餐后的主频率及正常慢波节律比等均低于健康对照组（ P均＜0^．05）；观察组血清SS、GAS及MTL均低于健康对照组，血清VIP则高于健康对照组（P ＜0．05）；观察组NO、IL-1β、TNF-α高于健康对照组，5-HT低于健康对照组（ P ＜0．05）。不同分级患者的检测指标间也有显著性差异，表现为1级＞2级＞3级＞4级（ P均＜0．05）。结论糖尿病胃轻瘫患者胃电参数及多项血清指标的变化较大，并且不同分级的糖尿病胃轻瘫患者之间也存在显著性差异，因此对于疾病的监测价值较高。