六味安消胶囊联合奥美拉唑对功能性消化不良患者胃电参数及胃肠动力相关指标的影响

摘要

目的 探讨六味安消胶囊联合奥美拉唑对功能性消化不良患者胃电参数及胃肠动力相关指标的影响.方法 选取2014年12月~2016年7月于厦门大学附属第一医院接受治疗的功能性消化不良患者86例,将所有患者随机分为对照组和观察组,各43例,对照组给予奥美拉唑治疗,观察组在对照组基础上给予六味安消胶囊,比较2组的症状体征治疗总有效率、治疗前后的胃电参数及胃肠动力相关指标.结果 观察组治疗后的腹痛、腹胀、早饱及嗳气总有效率均高于对照组(P<0.05).治疗后3、7及14d,2组胃电参数与治疗前比较差异均具有统计学意义(P<0.05),且观察组正常慢波节律比、胃电主功率及胃电频率均高于对照组(P<0.05),胃动过缓百分比低于对照组(P<0.05);2组胃肠动力相关指标与治疗前比较差异均具有统计学意义(P<0.05),且观察组餐前及餐后MTL均高于对照组(P<0.05),餐前及餐后SS均低于对照组(P<0.05).结论 六味安消胶囊联合奥美拉唑治疗功能性消化不良患者临床疗效确切,可显著改善患者胃电参数及胃肠动力相关指标,改善临床症状.%Objective To study the Effect of Liuwei anxiao capsules combined with omeprazole for the gastric electrical parameters and gastrointestinal motility related indexes of patients with functional dyspepsia. Methods 86 patients with functional dyspepsia in our hospital from December 2014 to July 2016 were selected,and all the patients were randomly divided into control group and observation group,43 cases in each group,the control group were treated with omeprazole,the observation group were treated with Liuwei anxiao capsules on the basis of the control group,then the total effective rates of different symptoms,signs,gastric electrical parameters and gastrointestinal motility related indexes before and after the treatment of two groups were compared. Results The total effective rates of observation group with abdominal pain,abdominal distension,early satiety and belching were all higher than those of control group (P<0.05).3,7 and 14 days after treatment,compared with the pre-treatment, the difference of gastric electrical parameters between the two groups was statistically significant (P<0.05),the ratio of normal slow rhythm rhythm, main electrogastric power and electrogastric frequency in observation group were higher than those in control group (P<0.05),the percentage of bradycardia was lower than that in control group (P<0.05);there were significant differences in the indexes of gastrointestinal motility between the two groups before treatment (P<0.05),the level of MTL before and after meals was higher in the observation group than that in the control group (P<0.05), and the levels of SS before and after meals were lower than those in the control group (P<0.05). Conclusion Liuwei anxiao capsules combined with omeprazole in the treatment of functional dyspepsia in patients with significant effect,can significantly improve the patient's gastric electrical parameters and gastrointestinal motility related indicators,and improve the clinical symptoms.