Objective To observe the variation characteristics of proinflammatory cytokines in patients with prostatic hyperplasia and prostatitis.Methods From 2012 June to 2014 January, 70 cases of hospitalized patients with disease of pros-tate, prostatic hyperplasia and prostatitis patients of 35 cases as the observation group, patients only with hyperplasia of pros-tate in 35 cases as the control group.Immunohistochemistry and immuno fluorescence quantitative PCR detection method were used for detection of proinflammatory cytokines, including interleukin 8 (IL-8), fibroblast growth factor 2 (FGF-2) and ma-trix metalloproteinase 2 ( MMP-2 ) , transforming growth factor beta ( TGF-β1 ) .And then through the immunohistochemical method to detect the tumor necrosis factor alpha (TNF-α),interleukin 6 (IL-6) and cluster of differentiation 3 (CD3) con-tent;finally, the detection results were statistical analyzed.Results The observation group’s IL-8, FGF-2 and MMP-2 pro-tein and IL-8 mRNA, FGF-2 mRNA and MMP-2 mRNA were higher than those in control group ( t =2.540 1, t =2.859 9, t =12.755 1, t =19.124 5, t =12.294 4, t =8.532 3, P <0.01);TNF-αlevel was higher than the control group but the difference was not statistically significance ( t =1.427 5, P >0.05), IL-6, CD3 level were higher than that of the control group ( t =3.942 0, t =6.988 1, P <0.01); bFGF-2 protein with moderate expression in the control group was 37.1%, which was lower than those in the observation group’ s 80%, the TGF-β1 protein moderate and above expression in the control group was 20%, which was lower than that of the observation group’s 82.8%(χ2 =2.721 8,χ2 =2.6784, P <0.01).Con-clusion The expression of proinflammatory cytokines in patients with benign prostatic hyperplasia and prostatitis was higher than patients with benign prostatic hyperplasia, prostatitis may change benign prostatic hyperplasia.%目的：观察促炎性细胞因子在前列腺增生症合并前列腺炎患者中的变化特点。方法选取2012年6月—2014年1月住院的前列腺疾病患者70例，前列腺增生症合并前列腺炎患者35例为观察组，单纯患有前列腺增生症患者35例为对照组。采用免疫组化方法和免疫荧光定量PCR检测法对患者的促炎性细胞因子进行检测，包括白介素8（IL－8）、成纤维生长因子2（FGF－2）和基质金属蛋白酶2（MMP－2）、转化生长因子－β（TGF－β1）。然后再通过免疫组织化学法检测患者的肿瘤坏死因子－α（TNF－α）、白介素6（IL－6）和分化簇3（CD3）的含量；最后对检测结果进行统计分析。结果观察组IL－8、FGF－2和MMP－2蛋白及IL－8 mRNA、FGF－2 mRNA和MMP－2 mRNA水平均高于对照组（ t ＝2．5401、2．8599、12．7551、19．1245、12．2944、8．5323， P均＜0．01）；TNF－α水平高于对照组但差异无统计意义（ t ＝1．4275， P ＞0．05），IL－6、CD3水平高于对照组（ t ＝3．9420、6．9881， P ＜0．01）；bFGF－2蛋白表达中度以上患者对照组占37．1％低于观察组的80．0％，TGF－β1蛋白表达情况中度及以上患者对照组占20．0％低于观察组的82．8％（χ2＝2．7218、2．6784， P ＜0．01）。结论促炎性细胞因子在前列腺增生症合并前列腺炎患者中均较单纯前列腺增生症患者高表达，前列腺炎可能影响前列腺增生症的变化。
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