小泛素样修饰蛋白4基因163A/G多态性与2型糖尿病肾病的相关性研究

摘要

目的 探讨小泛素样修饰蛋白4 (SUMO4)基因163 A/G多态性与2型糖尿病肾病(DN)的相关性.方法运用聚合酶链反应一限制性片段长度多态性(PCR-RFLP)方法对232例T2DM患者,其中正常白蛋白尿103例(N-UAlb组)、微量白蛋白尿65例(M-UAlb组)、大量白蛋白尿64例(L-UAlb组),以及102名健康对照(NC组)的SUMO4基因163 A/G多态性进行检测,并比较各组间基因型频率、等位基因频率及相关临床资料.结果 NC组和T2DM组基因型和等位基因频率无统计学差异；M-UAlb和L-UAlb组的GA基因型频率高于N-UAlb组(P＜0.05).结论在昆明地区汉族人群中,SUMO4基因GA基因型可能是DN发生的危险因素.%Objective To investigate the association of small ubiguitin-like modifer 4(SUMO4) gene 163 A/G polymorphism with type 2 diabetic nephropathy. Method The polymorphism of SUMO4 gene 163 A/G was detected by PCR-RFLP in 102 normal controls (NC group) and 232 patients with type 2 diabetes, including 103 normal albuminuria (N-UAlb group) , 65 microalbuminuria (M-UAlb group) , 64 macroalbuminuria (L-UAlb group). The genotype and allele frequencies and relative clinical data were compared among groups. Result The GA genotype frequency was significantly higher in DN(M-UAlb+ L-UAlb) group than in N-UAlb group. Conclusion The SUMO4 gene GA genotype may be a risk factor for diabetic nephropathy in Kunming Han Chinese.