System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modifier Target Proteins and Acceptor Lysines Relevant for Genome Stability

摘要

Our study reveals how SUMO regulates a network of target proteins in response to replication stress to coordinate the cellular DNA damage response. This network not only consists of known DNA damage response factors, but also includes replication factors, transcriptional regulators, chromatin modifiers, and centromeric proteins, revealing how a post-translational modification is able to orchestrate a large variety of different proteins to integrate different nuclear processes with the aim of dealing with the induced DNA damage.