糖耐量正常的向心性肥胖患者8-异前列腺素水平及其与胰岛素抵抗的关系

摘要

Objective To investigate the level of 8-iso-prostaglandin F2α (8-iso-PGF2α)and its relationship with insulin resistance in central obese patients with NGT.Methods Two hundred and twenty-two subjects were enrolled and divided into two groups: central obese group (n= 123) and normal control group(NC, n=99).The central obese group was subdivided into insulin resistance(IR) group and non-IR group.Serum 8-iso-PGF2α, malondialdehyde (MDA), free fatty acids (FFA), IL-6, TNF-α, and lipid were measured.Results Compared with the control group, the levels of 8-iso-PGF2α(P= 0.001),body mass index(BMI), waist circumference(WC), triglyceride (TG), cholesterol (TC), high density lipoprotein(HDL), FFA, MDA and insulin resistance index (HOMA-IR) significantly increased in obese group(all P＜0.05), and they increased even more in IR sub-group than those in non-IR sub-group.The level of 8-iso-PG-F2α had independently positive correlation with HOMA-IR.Conclusion Oxidative stress increases in central obese patients with NGT, and it plays an important role in insulin resistance.The level of serum 8-iso-PGF2α is a better parameter indicating the extent of oxidative stress.%目的 观察向心性肥胖患者的8-异前列腺素(8-iso-PGF2a)水平及其与胰岛素抵抗的关系.方法 筛选糖耐量正常的向心性肥胖患者(包括胰岛素抵抗与无胰岛素抵抗者)及正常对照组.分别测定血清8-iso-PGF2a,丙二醛(MDA),游离脂肪酸(FFA)等.结果 向心性肥胖组8-iso-PGF2a、MDA、胰岛素抵抗指数(HOMA-IR)、FFA均显著高于对照组(P＜0.05).8-iso-PGF2a差异最显著(P＜0.01),且与FFA、BMI及甘油三酯(TG)呈显著正相关.胰岛素抵抗亚组的8-iso-PGF2a水平显著高于无胰岛素抵抗亚组.多元回归分析显示,8-iso-PGF2a与HOMA-IR相关性最强.结论 糖耐量正常的向心性肥胖患者氧化应激增强,且氧化应激是胰岛素抵抗的重要危险因素,循环中子8-iso-PGF2a水平能更好地反映其程度.