compound, pharmaceutical composition, method for treating a condition that is regulated or normalized via dpp-iv inhibition, method for treating a metabolic disorder, method for treating type ii diabetes, method for lowering blood glucose, method for treating and prophylaxis of a disease, method for treating undamaged insulin-resistant glucose tolerance, method for the manufacture of a pharmaceutical composition and process for the preparation of compounds

摘要

COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD TO TREAT A CONDITION THAT IS REGULATED OR NORMALIZED BY DPP-IV INHIBITION, METHOD TO TREAT METABOL DIABETY METHOD TYPE II, METHOD DIABETARY METHOD DISEASE, METHOD FOR TREATING UNINTERRUPTED TOLERANCE OF INSULIN RESISTANT GLUCOSE, METHOD FOR MANUFACTURING A FAMOUS COMPOSITION AND PROCESS FOR PREPARING COMPOUNDS. The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of formula (1) wherein Y is -S (O) -M-, -CH-2 ~, -CHF, OR -CF ~ 2 ~; m is 0, 1, or 2; X is a bond, C 1 -C 6 alkyl, or -C (= o) - the dashed line ¢ ----! on the carbocyclic ring represents an optional double bond; R¹ is a substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl ring, substituted or unsubstituted heterocyclylalkyl ring, substituted or unsubstituted heteroarylalkyl, -CN, - COOR³, -CONR³R¬ 4¬, -OR³, -NR³R¬ 4¬, or NR³COR¬ 4¬; R 2 is hydrogen, nitrile (-CN), COOH, or isomer of a carboxylic acid (such as SO ~ 3 ~ H, CONOH, B (OH) ~ 2 ~, P0 ~ 3 ~ R³R¬ 4¬, SO ~ 2 ~ NR³R¬ 4¬, tetrazole, -COOR³, -CONR³R¬ 4¬, -NR³COR¬ 4¬, or -COOCOR³).