目的：观察胰岛β细胞分泌功能与胰岛素抵抗指数（HOM A‐IR）在T2DM中的变化。方法 T2DM患者268例，行75 g OGTT或100 g馒头餐试验，以及C‐P释放试验，比较组间各项相关指标的差异。结果与病程＜5年组比较，病程＞10年组胰岛β细胞功能（HOMA‐β）下降（P＜0.05）。病程＞10年组随FPG增加，HOMA‐β下降（P＜0.01），HOMA‐IR增加，但差异无统计学意义（P＞0.05）。结论长期良好的控制血糖，可延缓胰岛β细胞功能的衰竭。病程对HOM A‐β的损伤低于高血糖。%Objective To evaluate β cell function ,insulin resistance and their changes in patients with type 2 diabetes mellitus (T2DM ). Methods A total of 268 T2DM patients were enrolled in this study. 75 g OGTT or 100 g steamed bread meal test and C‐peptide release test were measured in all the subjects. Results Theβ cell function index (HOMA‐β) decreased significantly during the progress of T2DM (P< 0.05). In T2DM duration> 10 years group ,the decrease of HOMA‐β and the increase in HOMA‐IR associated with the increase of FPG did not reach the significant difference (P> 0.05).Together with the raising of FPG level ,HOMA‐βdecreased ,and the HOMA‐IR increased significantly (P<0.01). Conclusion Long‐term ,well‐controlled blood glucose could delay the exhaustion of β cell function. Injury to βcell function based on duration of diabetes is less severe than that of hyperglycemia.
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