糖尿病大鼠神经病理性疼痛的相关危险因素的分析

摘要

目的：分析 T2DM 大鼠神经病理性疼痛的相关危险因素。方法选取雌性清洁级Wistar大鼠分为非糖尿病标准饮食组（NdStd）、糖尿病高脂饮食疼痛组（DbHFP）、糖尿病高脂饮食非疼痛组（DbHFNP），各10只。定期检测每组体重、血糖、TG、TC、HDL‐C、LDL‐C、50％疼痛阈值，评估血脂与疼痛的关系。结果非条件Logistic回归分析显示，TG、LDL‐C、血糖为导致糖尿病神经病变疼痛的危险因素（P＜0.05），HDL‐C为糖尿病神经病变疼痛的保护因素（P＜0.05），而与 TC和体重无相关性（P＞0.05）。结论 TG、LDL‐C及血糖为导致糖尿病神经病毒疼痛的危险因素，HDL‐C为导致糖尿病神经病毒疼痛的保护因素。%Objective To explore the related risk factors for neuropathic pain in diabetic rats.Methods Female Wistar rats of clean grade were divided into three groups :Non diabetic standard diet (NdStd) group (n=10) ,diabetic high fat diet and pain (DbHFP) group (n=10) ,and diabetic high fat diet and no pain (DbHFNP) group (n=10).Body weight ,blood glucose ,TG ,TC ,HDL‐C ,LDL‐C and 50%pain threshold were measured regularly to assess the relationship between blood lipids and pain. Results Non‐conditional logistic regression analysis showed that pain threshold was negatively correlated with TG , LDL‐C and blood glucose(P<0.05) ,and positively correlated with HDL‐C (P<0.05). And there was no association between TC and body weight (P> 0.05). Conclusion Pain threshold of diabetic rats was negatively correlated with TG ,LDL‐C and blood glucose ,and positively correlated with HDL‐C.