Objective: To probe the value of evaluating in hepatic function in cirrhosis and the Child-Pugh staging using the apparent diffusion coefficient (ADC), exponential apparent diffusioncoefficient(eADC), the perfusion ADC (ADCperf) and perfusion eADC (eADCperf) values with different b values. Methods: Noninvasive magnetic resonance diffusion weighted imaging (DWI) was carried out in 53 cirrhotic patients. The ADC value and eADC value with low (100s/mm2, 200s/mm2 and 300s/mm2), moderate (400s/mm2 and 600s/mm2) and high (800 s/mm2, 1000 s/mm2 and 1 200 s/mm2) b values were analyzed on hepatic parenchyma. According to the difference in ADC and eADC values between low b value and high one, the perfusion ADC (ADCperf) and perfusion eADC (eADCperf) values were calculated. The relationship of ADC and eADC parameters with Child-Pugh staging and some serum markers of hepatic function were analyzed. Results: The statistic differences in the ADC value with low b value, the ADC and eADC values with moderate b value, and ADCperf value were seen among Child-Pugh stags (P<0.05). A negative correlation of the ADC value with low b value with AST was found(P=0.040, r=-0.554). The positive correlations of the ADC value with moderate b value with TP and ALB were also identified (P=0.006, r=0.814; P=0.034, r=0.570), whereas the correlation with GLO was reverse (P=0.017, r=-0.601). The ADCperf value was negatively related to AST (P=0.021, r=-0.643). No relationships were identified between other parameters above(P>0.05). Conclusion: DWI can be used for the liver cirrhosis staging, and the ADC parameters may reflect the hepatic function in cirrhosis to some degrees.%目的:探讨不同b值表观扩散系数(ADC)值、指数化表观扩散系数(eADC)值以及灌注ADC值和eADC值在肝硬化分级及肝功能损害评估方面的价值.方法:对53例肝硬化患者肝脏进行DWI扫描,并计算低(100 s/mm2、200 s/mm2和300 s/mm2)、中(400 s/mm2和600 s/mm2)和高(800s/mm2、1 000 s/mm2和1 200 s/mm2)b值时肝组织的ADC值和eADC值,然后根据低、高b值时ADC和eADC值的差异计算灌注ADC和eADC值.分析DWI各测量参数与Child-Pugh分级及与临床肝功能血清检测指标之间的关系.结果:低b值ADC值、中b值的ADC和eADC值以及灌注ADC值在Child-Pugh分级之间均见统计学差异(P＜0.05),其余测量值未见统计学差异(P＞0.05).低b值ADC值与AST负相关(P=0.040,r=-0.554),中b值ADC值分别与TP、ALB正相关(P=0.006,r=0.814; P=0.034,r=0.570),但与GLO负相关(P=0.017,r=-0.601),灌注ADC值也与AST负相关(P=0.021,r=-0.643),其余参数之间均未见相关性(P＞0.05).结论:利用DWI技术可对肝硬化的程度进行分级,ADC值相关参数也可在一定程度上反映肝硬化时肝功能情况.
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