Objective: Multidrug resistance is the main cause for the patients with cholangiocarcinoma for not responding to chemotherapy. The expression of lung resistance protein (LRP), glutathione P-glycoprotein(P170) were investigated in cholangiocarcinoma. Methods: The expression of LRP and P170 in 21 cases of cholangiocarcinoma were measured by RT-PCR methods, while 8 cases of choledochitis served as the control group. Results: The positive rate of LRP, P170 mRNA in cholangiocarcinoma were 76.2％, 66.7％ respectively, significantly higher than those of control group(P＜0.05).Their expressions were not related to gender, age, staging, differentiation and lymph node metastasis (P＞0.05). Conclusion: LRP and P170 were overexpressed in various degrees in cholangiocarcinoma without chemotherapy, and may be related to the primary multidrug resistance of the tumors.%目的:探讨胆管癌组织中LRP和P170的基因表达情况及其临床意义.方法:收集手术切除的胆管癌标本21例作为实验组,另取8组胆管炎症标本作为对照组,采用RT-PCR方法检测标本中LRP及P170 mRNA的表达.结果:LRP及P170 mRNA在胆管癌组织中的表达阳性率分别76.2%和66.7%,显著高于对照组(P<0.05),上述指标与性别、年龄、病理分期、分化程度、淋巴结转移均无关(P>0.05).结论:LRP及P170在未经过化疗的胆管癌组织中均有不同程度的高表达;胆管癌的原发性多药耐药可能与LRP及P170有关.
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