摘要：
Objective To observe the expression of lung resistance protein (LRP) and multidrug resistance protein (MRP) in different molecular subtypes of breast cancer,and discuss their significances.Methods using immunohistochemical method in 105 cases of breast cancer for molecular classificiation,and detect the expression of LRP and MRP in different molecular subtypes by using immunohistochemical method,and analyze their relationships with the molecular subtypes,estrogen receptor (ER) and human epidermalgrowth factor receptor-2 (Her-2).Results LRP has high expression in luminal subtype B,and the difference has statistically significance.The positive expression of MRP in the luminal A,luminal B,overexpression of Her-2,basal like and naked exression breast carcinoma are 62.50％,75.00％,54.55％,66.67％,70.00％ respectively,the difference has not obvious statistical significance.The positive expression of LRP has correlation with ER positive expression (r =0.28,P ＜ 0.05),and has not obvious correlation with Her-2 positive expression (r =0.001,P ＞ 0.05).The positive expression of MRP has not obvious correlation with ER and Her-2 positive expression (r =0.059,P ＞ 0.05;r =0.008,P ＞ 0.05).The positive expression of LRP has positive correlation with MRP positive expression (r =0.309,P ＜ 0.05).Conclusion LRP can predict the endogenous drug resistance of breast cancer,especially in luminal subtype B.%目的 观察乳腺癌各分子亚型中肺耐药蛋白(LRP)和多药耐药蛋白(MRP)的表达,探讨其在乳腺癌表达中的意义.方法 采用免疫组织化学方法对105例乳腺癌组织进行分子分型,并检测LRP和MRP在乳腺癌各分子亚型中的表达,分析它们与各分子亚型及与雌激素受体(ER)、人类表皮生长因子受体-2(Her-2)之间的关系.结果 LRP在腺腔B型高表达(87.5％),差异有统计学意义;MRP在腺腔A型、腺腔B型、过表达型、基底样型和裸表达型乳腺癌的阳性表达率分别为62.50％、75.00％、54.55％、66.67％、70.00％,差异无统计学意义(P＞0.05).LRP与ER之间明显相关(r =0.28,P＜0.05),与Her-2无明显相关(r=0.001,P＞0.05);MRP与ER、Her-2均无明显相关(r=0.059,P＞0.05;r =0.008,P＞0.05).LRP和MRP之间呈明显正相关(r=0.309,P＜0.05).结论 LRP可预测乳腺癌尤其是腺腔B型乳腺癌的内源性耐药.
