Objective To observe the relationships of white blood cell counts with cardiac troponin Ⅰ (cTnI) and arrhythmia in the patients with acute myocardial infarction (AMI), and to probe the predictive value of white blood cell counts in the occurrence of arrhythmia. Methods 157 AMI patients without reperfusion we divided into 4 groups according to the level of white blood cell counts:group G1 ＜8.0 × 109/L 35 patients; group G2 8.0 × 109/L ～ 12.0 × 109/L 43 patients; group G3 12. 0 × 109/L ～ 16.0 × 109/L 42 patients; group G4 ＞ 16.0 × 109/L 37 patients. We measured cTnI and CK- MB in every group patients, counted incidence rate of arrhythmia and analysed the relationship among them. Results There were significant differences in the concentration of cTnI and CK - MB among four groups patients(P ＜0.01), G3 and G4 were higher than Gland G2(P ＜0.01). There were significant differences in the incidence rate of arrhythmia of four groups (sinus tachycardia, atrial fibrillation, ventricular premature beats, ventricular tachycardia, ventricular fibrillation, AVB, BBB) ( P ＜ 0.01 ) , the incidence rate of arrhythmia of G3 and G4 were higher significantly than those of G1 and G2 by pairwise comparison ( P ＜ 0.01 ). The level of white blood cell counts were related to the incidence rate of arrhythmia positively ( r= 0. 957, P ＜ 0.01 ). Conclusion The higher the level of WBC counts in patients with AMI were, the larger the area of myocardial infarction were and the higher the incidence rate of arrhythmia were, especially malignant arrhythmia.%目的 观察急性心肌梗死(AMI)患者急性期血白细胞计数与肌钙蛋白、心律失常的相互关系,探讨血白细胞计数对AMI心律失常发生的预测价值.方法 将未行再灌注治疗的157例AMI患者根据血白细胞计数分为四组:G1组(<8.0×109/L)35例、G2组(8.0×109/ L～12.0×109/L)43例、G3组(12.0×109/L～16.0×109/L)42例、G4组(＞16.0×109/L)37例,测定各组患者心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)水平,统计各组患者心律失常的发生率,且对其之间的相关性进行分析.结果 四组患者cTnI及CK-MB水平比较差异有统计学意义(P<0.01),G3、G4组显著高于G1、G2组(P<0.01).四组患者心律失常(窦速、房颤、室早、室速、室颤、AVB、BBB)的发生率比较差异有统计学意义(P<0.01),G3、G4组显著高于G1、G2组(P<0.01).血白细胞计数与心律失常发生率呈正相关(r=0.957,P<0.01).结论 AMI患者血白细胞计数越高,心肌梗死面积越大,心律失常特别是恶性心律失常的发生率越高.
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