Objective To investigated the correlation between severity of acute pancreatitis and serum ghrelin concentrations. Methods Blood samples were collected three times (at admission, after 48 hours, and at discharge) from patients admitted with acute pancreatitis. We divided the patients into non - risk and risk groups. The risk group was defined as the presence of at least one of following risk factors for severe acute pancreatitis: Ranson score ≥ 3, acute physiology and chronic health evaluation (APACHE) Ⅱ score ≥8, C -reactive protein ( CRP) ≥150 mg/L, and CT severity index was Dor E. Serum ghrelin concentrations were measured by ELISA and analyzed based on clinical and biochemical parameters. Results A total of 55 patients was enrolled in this study: 29 in the non - risk group and 26 in the risk group. At admission, the ghrelin concentration was significantly higher both in the non - risk group ( P = 0. 021) and risk group ( P = 0. 019 ) compared with the control group. The rise in the ghrelin level was directly related to 48 - hour Ranson (P = 0. 000) and 24 - hour APACHE I scores (P = 0. 000) . The overall ghrelin concentration was significantly lower at admission than at discharge ( P = 0. 002) . Conclusion Patients with risk factors for severe acute pancreatitis have higher serum ghrelin concentrations.%目的 观察血清生长素水平与急性胰腺炎(AP)病情严重程度的相关性.方法 选择我院2010-01～2011-05收治的急性胰腺炎患者55例,将其分为无风险组(29例)和有风险组(26例).有风险组至少存在一种重症急性胰腺炎的危险因素:Ranson评分≥3分;APACHEⅡ评分≥8分;C-反应蛋白(CRP)≥150 mg/L;CT分级为D、E.测定其入院时、入院48 h及出院时血清生长素水平.结果 无风险组和有风险组患者的血清生长素水平较正常对照组均显著升高(P值<0.05),有风险组较无风险组升高更为明显(P=0.043).所有患者血清生长素水平与48 h Ranson和24 h APACHEⅡ分值均呈显著正相关(相关系数分别为0.675和0.751,P值均为0.000).所有患者入院时的生长素浓度均低于出院时(P=0.002).结论 急性胰腺炎患者的血清生长素水平升高,有重症急性胰腺炎危险因素患者的血清生长素水平增加更为明显.生长素水平的测定有助于对急性胰腺炎严重程度的评估.
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