帕金森病异态睡眠

摘要

睡眠障碍为帕金森病非运动并发症的常见临床症状,其中异态睡眠是近年来帕金森病相关睡眠障碍的研究热点.包括快速眼动睡眠期行为障碍、觉醒障碍和睡眠相关运动障碍；而觉醒障碍则可分为白天过度嗜睡和睡眠发作,睡眠相关运动障碍包括不宁腿综合征和周期性腿动.其中,快速眼动睡眠期行为障碍和白天过度嗜睡可以发生在帕金森病运动症状之前,并有可能成为帕金森病的早期生物学标志.此外,部分异态睡眠的发生与抗帕金森病药物有关.因此,了解帕金森病患者的睡眠障碍,不仅有助于改善帕金森病患者生活质量,而且可使早期筛查帕金森病易感人群、尽早开展神经保护治疗成为可能.%Sleep disorders,as one of the most common non-motor manifestations of Parkinson's disease (PD),have caused serious impact on the quality of life in PD patients.Parasomnias as an important part of sleep disorders associated with PD,have become hot topics in recent years.Parasomnias include rapid eye movement sleep behavior disorder (RBD),sleep-related movement disorders and wakefulness disturbance,while wakefulness disturbance consists of excessive daytime sleepiness (EDS) and sleep attacks.Some of these disorders,including RBD and EDS may occur before the motor symptoms of PD and become potential early markers of the disease.Sleep-related movement disorders include restless legs syndrome (RLS) and periodic limb movement (PLM).In addition,a part of them such as EDS is related to pharmacologic treatment.So get a better knowledge of sleep disorders in PD,will not only help to improve the quality of life in PD through timely intervention,but make it possible to identify people at risk in developing PD and carry out neuroprotective therapy as early as possible.