12种中药单体对APPswe/PS△E9转基因痴呆模型小鼠学习记忆作用的比较

摘要

目的 利用APPswe/PS△E9转基因阿尔茨海默病小鼠模型探索治疗痴呆有效的中药单体.方法 根据目前的研究资料,选定12种中药单体,加入鼠粮中对APPswe/PS△E9双转基因小鼠在5月龄开始进行治疗,以安理申作为阳性药对照,4周后进行水迷宫实验,并与安慰剂组小鼠进行比较.结果 在水迷宫实验中,与安慰剂组相比,吴茱萸碱能够显著缩短寻找平台的潜伏期,显著增加穿过原平台区的次数.结论 吴茱萸碱能够显著改善APPswe/PS△E9痴呆模型小鼠的学习记忆能力.%Objective To analyze the therapeutic effects of 12 herbal monomers on APPswe/PS1ΔE9 transgenic mice,and to explore promising candidates for treatment of Alzheimer disease. Methods APPswe/PS1 ΔE9 transgenic mice at age of 5 months were randomized into 14 groups. One group was vehicle group (placibo) and one group was Aricept group as positive control. The other 12 groups were used for treatment with the 12 herbal monomers ,respectively. The littermates of no-negative mice were used as normal control. Morris water-maze test was performed at 4 weeks after treatment to assess the nervous function. Results The evodiamine-treated mice showed significantly decurtated latency and increased number of crossings of the removed-platform area in Morris water maze teat, compared with that of the vehicle group. Conclusions Evodiamine treatment can improve the learning and memory ability in APPswe/PS1ΔE9 double-transgenic mice.