Effect of plant compound curcumin on the expression of a-synuclein in hippocampal neurons of APPswe/PS1dE9Double transgenic mice

摘要

In this study, we aim to investigate the effect of curcumin on the expression of a-synuclein in the APPswe/PSldE9Double transgenic mice. APPswe/PS1dE9Double transgenic mice were used as AD (Alzheimer's disease) model and fed with different concentrations of curcumin every day for 6 months, then immunohistochemistry method were used to detect the expression of a-synuclein in hippocampus of mice. The expression of a-syn in hippocampal neuron was decreased significantly after treated with 0.16g/kg to 1.0g/kg curcumin, the change was apparent in dose-dependent manner (P<0.05). a-synuclein pay an important role in the genesis and development of Alzheimer's disease and decreased level of a-synuclein might contribute to the neuroprotective effect of Curcumin, which may become a new target for the prevention and treatment of Alzheimer's disease.