Premature ovarian failure (POF) is a typical heterogeneous disease developed due to diverse causes. In recent years, studies show a significant increase of its incidence. POF seriously affect physical and mental health of women. A reproducible and reliable animal model plays an important role in POF research. This review will summarize the relatively successful animal models established by researchers at home and abroad and briefly discuss their advantages and disadvantages.%卵巢早衰是一种典型异质性疾病,病因复杂多样.近年来,卵巢早衰的发病率有明显上升趋势,严重影响妇女身心健康和生活质量.建立一种理想可靠的卵巢早衰动物模型对研究卵巢早衰有着重要的临床意义.本文就国内外学者建立的卵巢早衰动物模型作一综述,讨论比较各种方法的优缺点.
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