甘肃省陇南市部分人群代谢综合征现况调查

摘要

Objective To investigate the prevalence of metabolic syndrome (MS) in Longnan. Meth-ods A multistage stratified cluster sampling method was conducted. A total of 1149 adults (range 18~91 years old) from 5 cities located in different areas of Gansu province were included in the analysis and all of them un-derwent physical examinations. MS was diagnosed under the modified 2005 National Cholesterol Education Program Adult Treatment PanelⅢ (ATPⅢ) guidelines as well as the 2004 Chinese Diabetes Society (CDS) guidelines. Results Longnan city population:using the modified ATPⅢcriterion for diagnosis, the unadjust-ed prevalence of MS was 35.86%(40.98%in males and 30.19%in females, respectively), and the age-ad-justed prevalence was 41.04%, which were higher than under the CDS criterion, the unadjusted prevalence of MS was 22.37% (28.57%in males and 15.37%in females, respectively), and the age-adjusted prevalence was 26.85%. Between ATPⅢand CDS criterion,MS'morbidity rate of males was higher than women's, and the difference had statistical significance(χ2ATPⅢ=14.25,χ2CDS=28.27, Pall<0.05). MS's morbidity rates of different ages groups all showed a trend of first increase and then decrease. The highest morbidity rate was 45~54 age group (ATPⅢ:43.98%,CDS:29.22%). MS's morbidity rates all had gender difference at age increasing trend under two diagnostic criteria. MS's morbidity rates of males were all higher than that of females except 65~74 age group. The prevalence of metabolic syndrome was increased with age. Combination with central obesity , high TG hyperlipidemia, low HDL-C hyperlipidemia, hypertension and hyperglycemia were the most fre-quently seen. Significant difference was found in the prevalence of MS between different ethnicities in Longnan. The prevalence of MS increased with age. Combination with central obesity , high TG hyperlipidemia and hy-pertension was most frequently seen. Conclusion The prevalence of MS in the 5 cities in Gansu is higher than that domestically formerly reported.%目的：调查陇南市部分人群代谢综合征（metabolic syndrome， MS）流行情况。方法本次调查采用多级分层整群抽样的方法，选择2012年6月至2013年12月在陇南市第一人民医院进行健康体检的人群共1149例作为研究对象，采用国际心肺血液协会对美国国家胆固醇教育计划成人治疗专家组第三次报告（Adult Treatment PanelⅢ， ATPⅢ）修订后的标准以及中华医学会糖尿病学分会（Chinese Diabetes Society， CDS）关于MS的建议（CDS标准）这两种MS诊断标准进行分析。结果在1149例陇南市体检人群中，按照ATPⅢ标准，MS总患病率（35.86％），男、女性患病率（40.89％，30.19％）及标化患病率（41.04％）均高于CDS标准[MS总患病率（22.37％），男、女性患病率（28.57％，15.37％）及标化患病率（26.85％）]。且在这两种诊断标准下，男性MS患病率均显著高于女性MS患病率，差异均有统计学意义（χ2ATPⅢ＝14.25，χ2CDS＝28.27，P均＜0.05）。不同年龄段体检人群MS患病率都呈现出先增高再降低的趋势，最高患病率出现在45～54岁年龄组（ATPⅢ：43.98％，CDS：29.22％）；但MS患病率的增龄趋势都具有一定的性别差异，除65～74岁年龄组外，MS患病率男性均高于女性，女性MS患病率随着年龄的增长先升高再降低，女性最高患病率出现在65～74岁年龄组（ATPⅢ：40.24％，CDS：20.73％）。男性45～54岁年龄组MS患病率最高（ATPⅢ：52.81％，CDS：39.33％），随后逐渐降低。1149例体检人群中男性、女性均为高血压（ATPⅢ：男59.11％，女45.19％）和高TG血症（CDS：男55.01％，女39.07％）异常检出率最高。不同指标组合的MS危险因素构成比最高为TG／血压／BMI（CDS标准）和FBG／TG／HDL－C／血压／WC（ATPⅢ标准）。结论陇南市部分人群MS患病率相对于国内其他地区均处于较高水平。