血清AFP、FER和CA19－9联合检测在原发性肝癌诊断中的意义

摘要

目的：探讨血清肿瘤标志物甲胎蛋白（alpha－fetoprotein， AFP）、铁蛋白（ferritin，FER）、糖链抗原19－9（carbohydrate antigen 19－9， CA19－9）联合检测在原发性肝癌（primary hepatic carcinoma， PHC）诊断中的意义。方法选择2013年3月至2014年3月期间于我院就诊的PHC患者91例、肝硬化患者57例及健康体检者95例，采用电化学发光法检测受试者血清AFP、FER、CA19－9的水平，对检测结果进行统计学分析。结果 PHC组、肝硬化组、正常对照组中AFP、FER和CA19－9的检测结果差异均有统计学意义（P均＜0.05）；PHC组和肝硬化组AFP、FER和CA19－9的检测结果均高于正常对照组，且差异均有统计学意义（P均＜0.05）；PHC组AFP、FER和CA19－9的检测结果均高于肝硬化组，且差异均有统计学意义（P均＜0.05）。 PHC组和肝硬化组各组内AFP、FER和CA19－9及联合检测的阳性率比较差异均有统计学意义（P均＜0.05）；PHC组和肝硬化组各组内AFP、FER和CA19－9联合检测的阳性率均高于三指标单独检测的阳性率，且差异均有统计学意义（P均＜0.05）。结论血清AFP、FER、CA19－9联合检测能提高PHC的检出率，可用于PHC的鉴别诊断及高危人群的筛查。%Objective To assess the clinical significance of alpha-fetoprotein (AFP), ferritin (FER) and carbohydrate antigen 19-9 (CA19-9)combine detection in diagnosis of primary hepatic carcinoma (PHC). Methods 91 cases PHC patients, 57 cases hepatic cirrhosis patients and 95 cases healthy controls from March 2013 to March 2014 in our hospital were collected. The levels of AFP , FER and CA19-9 of all subjects were detected, and the results were analyzed statistically. Results There were statistical significance in the differences of AFP, FER and CA19-9 levels among three groups (Pall<0.05). The AFP, FER and CA19-9 levels in PHC group and hepatic cirrhosis group were all higher than that of control group , and the differences all had statistical significance (Pall<0.05). The AFP, FER and CA19-9 levels in PHC group were all higher than that of hepatic cirrhosis group, and the differences all had statistical significance (Pall<0.05). There were statistical significance in the differences of AFP, FER, CA19-9 and combine detection positive rate in PHC group and hepatic cirrhosis group (Pall<0.05). The positive rate of combine detection in PHC group and hepatic cirrhosis group were all higher than that of AFP, FER and CA19-9 lonely detection, and the differences all had statistical significance(Pall<0.05). Conclusion The combine detection of AFP, FER and CA19-9 can improve the detection rate of PHC, and which have an important role in disease screening and differential diagnosis.