分子靶向治疗在妇科恶性肿瘤中的研究进展*

摘要

分子靶向治疗（molecular targeted therapy，MTT）作为肿瘤治疗的新手段，通过特异性靶向肿瘤发生发展中起关键作用的分子或相关细胞的信号转导通路控制细胞基因表达，从而抑制或杀死癌细胞，基于对细胞分子生物学及信号转导机制，在分子水平上对肿瘤细胞进行直接或间接的精确打击。肿瘤分子靶向治疗因其具有疗效高、不良反应低的特点而备受瞩目，其出现为肿瘤的治疗开辟了新的领域和广阔的前景。本文就妇科恶性肿瘤中分子靶向治疗的研究进展进行综述。%Molecular targeted therapy (MTT) refers to a new therapy designed to interfere with a specific molecular target or signaling pathway that may have a significant influence in tumor growth or progression. MTT can inhibit cell proliferation and induce apoptosis by specific interventions in the signaling pathways of tumor cells. MTT exhibits potential as an effective treatment against cancer. This approach can improve the ability to kill cancer cells and reduce damage to normal tissues. MTT has gradually been used clinically in treating cancer and shown advantages over traditional methods. This paper reviews research progress in this targeted therapy to treat gynecological cancer.