肿瘤的发生不仅与外界多种致癌因素有关，还与机体自身免疫应答及遗传因素密切相关。 B7-H4为新近发现的免疫共刺激调节蛋白B7家族新成员，多种恶性肿瘤过表达。 B7-H4作为免疫反应的第二信号，调节免疫活性，参与肿瘤的发生、发展和预后。本文针对免疫共刺激分子B7-H4的结构、功能及其与妇科恶性肿瘤的关系作一综述。%The occurrence of tumor is not only closely related to a variety of carcinogenic factors from outside, but also keeps a close relationship with the body�s own immune response and genetic factors. B7-H4,a newly discovered immune regulatory proteins members of the family of B7, over-expresses in a number of malignant tumors. It acts as the second signal in the immune response, reg-ulates immune activity and promotes the occurrence, development and prognosis of tumors. As described below,we discussed structure, function of molecules B7-H4 and its new progression with gynecologic malignant tumors.
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