负性共刺激分子B7-H4与肿瘤免疫信号通路的研究进展

摘要

负性共刺激分子B7-H4与PI3K-AKT-mTOR信号转导通路有着重要联系, 同时PI3KAKT-mTOR信号转导通路是哺乳动物肿瘤免疫中重要的信号通路, 通过研究探讨B7-H4与PI3K-AKT-mTOR信号通路之间的内在联系, 从而讨论其在肿瘤发生、发展过程中的信号转导机制, 对于寻找作用于多种信号通路、多靶点的新药, 肿瘤的靶向治疗有重要意义.%The negative costimulatory molecule B7-H4 has an important relationship with the PI3KAKT-mTOR signal transduction pathway.Meanwhile, PI3K-AKT-mTOR signaling pathway is an important signal pathway in mammalian tumor immunity.Researching the relationship between B7-H4 and PI3K-AKT-mTOR signaling pathway was important to discuss the signal transduction mechanisms in tumor genesis and evolution.Besides, it is important to find new drugs that targeted therapy for tumors.