miR-17-92基因簇在骨肉瘤中的表达及其临床意义

摘要

Objective:To determine the expression of miR-17-92 cluster in osteosarcoma tissue samples and explore its associa-tion with clinical significance. Methods: Quantitative polymerase chain reactiom analysis was used to examine the expression of miR-17-92 cluster in osteosarcoma tissues. Normal bone tissues from 63 patients were matched, and the relationships between the ex-pression of miR-17-92 cluster and the clinicopathological features and prognosis of osteosarcoma were explored. Results:The relative expression of miR-17-92 cluster in osteosarcoma tissues was significantly higher than those in adjacent normal tissues (P<0.05). The high expression of miR-17-92 had a significant correlation with reduced survival (P=0.027). Conclusion:The expression of miR-17-92 cluster closely correlates with the occurrence and progress of osteosarcoma and may be used as an indicator for osteosarcoma prognosis.%目的：探讨人骨肉瘤组织和邻近正常骨组织中miR-17-92基因簇的表达情况及其临床意义。方法：运用Q-PCR法检测63例骨肉瘤组织及邻近部位正常骨组织中miR-17-92基因簇的表达水平，并分析miR-17-92基因簇表达与患者临床病理特征及预后的关系。结果：miR-17-92在所有组织中均有表达，且在肿瘤组织中表达明显高于在正常组织中的表达（P<0.05），另外， miR-17-92基因簇高表达患者预后更差，差异有统计学意义（P=0.027）。结论：miR-17-92基因簇在骨肉瘤组织和邻近正常骨组织中表达存在差异性，可能在骨肉瘤发生、发展过程中起重要作用，有望成为骨肉瘤患者预后一种新的指标。