Objective:To explore the factors affecting the postoperative prognosis of early cervical squamous cell carcinoma and inves-tigate the different radiotherapy techniques. Methods:A total of 100 postoperative patients of early cervical squamous cell carcinoma treated in Affiliated Tumor Hospital of Xinjiang Medical University and Affiliated Tumor Hospital of Sun Yat-sen University from March to September 2013 were enrolled in our study. The prognostic factors for these patients were analyzed. After being subjected to differ-ent postoperative radiotherapy techniques, the efficacy and complications of the techniques were assessed for patients, including 50 cases of conventional radiotherapy (CRT) and 50 cases of image-guided radiotherapy (IGRT). Results:The 3-year overall survival rate was 89%, and the 3-year disease-free survival rate was 78%. The 3-year overall survival rates of the CRT and IGRT groups were 78.57%and 89.06%, respectively. The difference between these rates was statistically significant (P=0.034). The 3-year survival rates of the CRT and IGRT groups were 66.67%and 87.36%, respectively. The difference was statistically significant (P=0.042). The incidence of ear-ly and late complications in the CRT group was higher than that in IGRT group, and the difference of P<0.05 was statistically significant. Multivariate analysis showed that postoperative radiotherapy, parametrial invasion, lymph node metastasis, lymphovascular space in-vasion, perineural invasion, and deep stromal invasion were the independent risk factors for the prognosis of patients with early stage cervical squamous cell carcinoma. Conclusion:Early prognosis of cervical squamous cell carcinoma results from the interaction of mul-tiple factors. The 3-year survival rate of the IGRT group was significantly better than that of the CRT group in the early stage of cervical squamous cell carcinoma. IGRT alleviates acute and chronic toxicities and helps improve the quality of life of patients.%目的:探讨影响早期宫颈癌患者术后预后的因素和不同放疗方式的疗效及并发症情况.方法:回顾性分析2013年3月至9月100例新疆医科大学附属肿瘤医院及中山大学附属肿瘤医院收治的早期宫颈癌术后患者资料,并对影响患者预后的因素进行分析.根据放疗方式分为常规放疗(conventional radiotherapy,CRT)组50例,图像引导调强放疗(image guided radiotherapy,IGRT)组50例,并比较两组的疗效和并发症情况.结果:100例患者3年生存率和无瘤生存率分别为89%和78%.CRT组和IGRT组3年生存率分别为78.57%和89.06%,两组比较差异具有统计学意义(P=0.034);CRT组和IGRT组3年无瘤生存率分别为66.67%和87.36%,两组比较差异具有统计学意义(P=0.042).CRT组和IGRT组早期、晚期并发症的比较差异具有统计学意义(P<0.05).单因素分析显示宫旁浸润、淋巴结转移、肿瘤浸润深度、淋巴脉管间隙浸润、神经侵犯、术后放疗与早期宫颈癌3年生存率相关(P<0.05).Cox多因素分析显示术后放疗方式、宫旁浸润、淋巴结转移、淋巴脉管间隙浸润、神经侵犯及肿瘤浸润深度均为影响早期宫颈癌患者预后的独立危险因素.结论:早期宫颈癌的预后是多因素相互作用的结果,术后IGRT组3年生存率明显优于CRT组,放疗不良反应小,有益于患者的生存质量.
展开▼
