迁移侵袭抑制蛋白在肿瘤发生发展中的作用及其临床意义

摘要

迁移侵袭抑制蛋白(migration and invasion inhibitory protein,MIIP)能够与胰岛素样生长因子结合蛋白2(insulin-like growth factor binding protein 2,IGFBP2)、组蛋白去乙酰化酶6(histone deacetylase 6,HDAC6)、p21活化激酶1、表皮生长因子受体、细胞分裂周期20(cell division cycle 20,cdc20)、拓扑异构酶等相互作用,抑制细胞增殖和迁移侵袭,进而抑制多种肿瘤的发生发展.最近的研究显示,MIIP还与病毒感染、细胞免疫有关.鉴于MIIP的作用涉及到多条肿瘤相关的信号通路及肿瘤治疗靶点,MIIP逐渐成为研究的热点.本文主要围绕MIIP的分子特征、功能和在多种肿瘤中的临床意义及作用机制进行综述.%Migration and invasion inhibitory protein(MIIP)inhibits cell proliferation,migration,and invasion,impeding tumorigenesis and tumor progression,by interacting with insulin-like growth factor binding protein 2(IGFBP2),histone deacetylase 6(HDAC6),p21 activated kinase 1(PAK1),epidermal growth factor receptor(EGFR),cell division cycle 20(CDC20),and topoisomerase.Recent studies revealed potential roles of MIIP in viral infection and cellular immunity.MIIP has become a research hotspot owing to its involvement in multiple signaling pathways and as a potential therapeutic target for tumors.This review summarizes the characteristics,functions, clinical significance,and possible pathogenic mechanisms of MIIP in multiple carcinomas.