Inhibitor of cell migration, invasion or angiogenesis through functional inhibition of PTK7 protein

摘要

The present invention relates to a cell migration, cell infiltration, or neovascularization inhibitor through the degradation of a function of the PTK7 protein. The inhibitor of the present inventioninhibits neovascularization, cell migration, cell infiltration, and cell adhesion caused by VEGF, and inhibits activation of PI3-kinase and Akt. Further, the inhibitor of the present invention inhibits the activation of FAK and paxilline, thus effectively inhibiting neovascularization, cell migration, and cell infiltration in a living body.