目的:回顾分析Ⅲa期非小细胞肺癌患者上皮型钙黏附蛋白(E-cadherin)和β-连接素(β-catenin)表达情况,探讨其对患者预后的相关性.方法:选取2005-2006年75例Ⅲa期非小细胞肺癌患者肿瘤组织标本构建组织芯片,经免疫组织化学方法完成E-cadherin和β-catenin染色,分析E-cadherin和β-catenin表达与患者临床、病理及预后的相关性.结果:73例患者中有22例患者术后3年存活,3年生存率为30.67%,其中3年无瘤生存率为29.33%.肿瘤组织E-cadherin表达全部位于细胞膜,其中微量表达18例,低表达26例,中表达23例,高表达8例;β-catenin细胞膜表达71例,细胞浆和核膜表达4例,其中微量表达27例,低表达26例,中表达19例,高表达3例.E-cadherin和β-catenin表达与肿瘤分化程度呈正相关,E-cadherin表达为患者术后3年无瘤生存率的独立预后因素,风险比(hazard ratio,HR)为0.48(P=0.015);β-catenin表达与患者术后3年无瘤生存率无显著相关.结论:E-cadherin和β-catenin表达与肿瘤分化程度呈正相关,E-cadherin表达量是IIIa期非小细胞肺癌患者术后3年无瘤生存率预后的独立预测因素.%Objective: To investigate the expression of E-cadherin and β-catenin as prognostic factors in stage Ⅲa non-small-cell lung carcinoma (NSCLC). Methods: Tumor samples were constructed by tissue microarray (TMA) and immunohistochemistry (IHC) to analyze the relationship between the patients'clinical significance and the E-cadherin,β-catenin expression. Results: A total of 22 cases survived after 3 years' follow up,the over-all survival was 30.67％ and the disease-free survival was 29. 33％. The number of trace,low, intermediate, and high-level expression of E-cadherin and β-catenin were19, 28, 28, 12 and 28, 32, 33, 4, respectively. There was a positive correlation between E-cadherin and β-catenin (P＜0. 001 ). Dedifferentiation was associated with reduced expression of both E-cadherin and β-catenin (P = 0. 001, P＜0. 001 ). E-cadherin expression was an independent prognostic factor for disease-free survival the hazard ratio (HR) was 0.48 (P = 0. 015). Conclusions: Reduced expression of E-cadherin and β-catenin correlates with poor differentiation. E-cadherin is an independent prognostic factor for stage Ⅲa NSCLCs 3 years'disease-free survival.
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