血清人软骨糖蛋白39在高血压患者外周血中的表达及意义

摘要

目的探索血清人软骨糖蛋白39（YKL-40）在高血压外周血中的表达及意义。方法住院接受诊疗的高血压患者列为观察组。另纳入健康体检者作为对照组。本研究共纳入观察组45例，对照组30例。分别检测两组的YKL-40、白介素-6（IL-6）、内皮素-1（ET-1）、C反应蛋白（CRP）等指标。结果观察组患者三酰甘油水平显著高于对照组，差异有统计学意义（t＝2．589，P＝0．012）。观察组患者外周血ET-1水平显著高于对照组（t＝10．900，P＜0．01）；观察组外周血 YKL-40显著高于对照组[（42．96±10．55）μg／L 比（28．18±7．25）μg／L；t＝6．686，P＜0．01]；观察组外周血CRP水平显著高于对照组，差异有统计学意义[（6．51±2．16）mg／L比（4．23±1．08）mg／L，t＝5．345，P＜0．01]。观察组患者血清YKL-40与CRP呈现显著正相关，具有统计学意义（r＝0．838，P＜0．01）；观察组患者血清 YKL-40与 ET-1呈现显著正相关，差异有统计学意义（r ＝0．816， P ＜0．01）。结论高血压患者血清YKL-40升高，且与炎症和代谢紊乱相关，可用以辅助临床诊疗。%Objective To explore the expression and clinical significance of serum cartilage glycoprotein 39 in patients with hypertension.Methods Forty-five patients with hypertension received treatment in our hospital from 2012 to 2015 were collected as observational group.Thirty healthy controls were enrolled as control group.Results The tri-glyceride,ET-1 and CRP of observational group was higher than those of control group,the difference was statistically significant (t=2.589,P=0.012;t=10.900,P<0.01;t=5.345,P<0.01).Correlation analysis showed the levels of YKL-40 had significant positive correlation with CRP and ET-1 (P<0.01 )in the observational group.Conclusion The level of YKL-40 increased in patients with hypertension,which may be associated with inflammation and metabolic disorders.